Best of five
- A. Otosclerosis
- B. Auditory neuropathy spectrum disorder
- C. Ménière's disease
- D. Superior semicircular canal dehiscence
- E. Presbycusis alone
An adult reports disproportionate difficulty understanding speech in noise. Pure-tone thresholds are mildly impaired, otoacoustic emissions are present, but auditory brainstem responses are absent and acoustic reflexes are abnormal. What diagnosis best explains this pattern?
Preserved outer-hair-cell activity with disordered neural synchrony and disproportionately poor speech perception is characteristic of auditory neuropathy spectrum disorder. Management requires specialist audiology and may include remote-microphone systems, hearing aids or cochlear implantation according to functional benefit.
A. Otosclerosis: Otosclerosis produces a conductive or mixed pattern and does not characteristically preserve emissions with absent neural responses.
B. Auditory neuropathy spectrum disorder: Preserved outer-hair-cell activity with disordered neural synchrony and disproportionately poor speech perception is characteristic of auditory neuropathy spectrum disorder. Management requires specialist audiology and may include remote-microphone systems, hearing aids or cochlear implantation according to functional benefit.
C. Ménière's disease: Ménière's causes fluctuating cochlear loss with episodic vertigo rather than this electrophysiological dissociation.
D. Superior semicircular canal dehiscence: A third-window disorder produces sound/pressure symptoms and characteristic conductive physiology, not absent ABR with preserved emissions.
E. Presbycusis alone: Age-related cochlear loss does not account for the defining neural-synchrony pattern.
If otoacoustic emissions were absent with a conventional sloping cochlear loss and proportionate speech scores, ordinary sensorineural hearing loss would be more likely.
Independent Clinora educational preparation material; not official JCIE content, an accredited programme, clinical advice, or a substitute for local policy and specialist judgement.
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